Peyronie’s Disease Treatment with Perovial
Perovial treatment for Peyronie’s disease is indicated for men with penile curvature in the acute phase, aiming to slow disease progression and relieve symptoms before considering surgery.
What is Perovial?
Perovial is an injectable medical device containing hyaluronic acid, specifically developed to treat the most acute phase of Peyronie’s disease. Its formula acts directly on the penile fibrotic plaque, helping reduce stiffness and progressive curvature, while also relieving associated pain.
The hyaluronic acid in Perovial has moisturizing, antioxidant, and antifibrotic properties, which help remodel tissue and restore elasticity of the tunica albuginea. Its administration is minimally invasive and requires an intralesional injection performed by a specialized urologist or andrologist, ensuring maximum efficacy and safety.
Perovial is the first injectable device with the specific indication for “treatment of the acute/active phase,” approved by the European Medicines Agency.
Benefits of Perovial treatment
Perovial offers advantages compared to other therapeutic approaches:
1
Effective local action
Hyaluronic acid is injected directly into the plaque, increasing drug concentration in the affected tissue.
2
Prevents progression
It helps limit curvature and pain associated with acute-phase Peyronie’s disease.
3
Safe and minimally invasive
It is an outpatient treatment with mild and manageable side effects.
This approach is especially recommended by urologists specializing in Peyronie’s disease in Spain, for those seeking early treatment before considering surgery or more invasive therapies.
How is Perovial administered?
Each injection is tailored to the size and location of the plaque, ensuring efficacy and safety. During treatment, sexual activity should be avoided for the first few days after injection to optimize results.

How is it applied?
Weekly intralesional injections

For how long?
10-12 weeks

Who administers it?
Administered by a urologist or andrologist experienced in Peyronie’s disease
Who is Perovial treatment for?
Perovial treatment is recommended for adult men with acute-phase Peyronie’s disease, especially those who present:
- Progressive penile curvature.
- Pain during erection.
- Impact on sexual function.
It is an early option that can reduce disease progression and improve quality of life, avoiding or delaying surgical interventions.
Possibles side effects of treatment
Like any intralesional injection, local and transient effects may occur with Perovial treatment for Peyronie’s disease:
Pain or tenderness at the injection site
Redness, swelling, or mild bruising
Rare localized inflammatory reactions
Want more information about Perovial treatment in Barcelona?
If you suspect you may have acute-phase Peyronie’s disease, at Andrology Barcelona we assist with diagnosis and advise on the best personalized treatment. Only a professional can determine if Perovial is suitable for your case and design a safe, individualized treatment plan.