Peyronie's disease is a condition that can cause pain, abnormal curvature of the penis, and erectile dysfunction. Its development is related to fibrosis in the penis; the formation of scar tissue (fibrotic plaques) in the tunica albuginea, the membrane surrounding the corpora cavernosa of the penis.
Although its exact origin is not completely determined, there are several causes that can influence its onset. As experts in Peyronie's disease in Barcelona, we know that it is essential to identify the possible reasons behind this disease in order to treat it effectively.
Causes of Peyronie's disease
Traumatic and mechanical causes
These are related to injuries, tissue damage and physical factors that can trigger the formation of fibrotic plaques in the penis.
Microtrauma and repetitive injuries
One of the possible causes of Peyronie’s disease is the presence of microtrauma or injury to the penis. When the injury does not heal properly, it can form a plaque of scar tissue, which causes curvature of the penis. Microtrauma and repetitive injuries can occur:
- During sexual intercourse.
- When participating in sports activities.
- Due to medical procedures, such as catheterizations.
Aging
Aging is an important risk factor. As men age, the body’s ability to repair tissues decreases, which can make them more susceptible to the formation of abnormal scars and, therefore, to Peyronie’s disease.
Connective tissue disorders
Certain connective tissue diseases may be related to the onset of Peyronie’s disease. These disorders affect the body’s ability to repair tissues properly, facilitating the formation of abnormal scars
Connective tissue disorders
Certain connective tissue diseases may be related to the onset of Peyronie’s disease. These disorders affect the body’s ability to repair tissues properly, facilitating the formation of abnormal scars on the penis.
It is estimated that Peyronie’s disease affects approximately 3-9% of adult men, although the actual prevalence may be higher due to the lack of diagnosis in mild or asymptomatic cases.
Causes biological and systemic
These are internal factors of the body that can influence the onset and progression of Peyronie’s disease.
Genetic factors
It has been observed that some men have family history related to the development of Peyronie’s disease, whether family members with this condition or with fibrotic disorders, such as Dupuytren’s contracture. Therefore, genetics is one of the causes of Peyronie to consider, as the risk of developing it increases exponentially if there is a family history.
Inflammation and autoimmune responses
Some research suggests that the immune system may be one of the causes of Peyronie’s disease. An uncontrolled inflammatory response after a penile injury could contribute to the formation of fibrotic plaques, affecting tissue elasticity and causing curvature.
Hormonal imbalances
Abnormal hormone levels, such as testosterone, can influence the development and be one of the causes of Peyronie. Although not a direct cause, certain studies suggest that a hormonal deficiency could affect tissue regeneration and promote the formation of fibrous tissue.
Vascular and metabolic diseases
Conditions such as diabetes, hypertension, and atherosclerosis can affect blood circulation in the penis. Poor vascularization can alter the healing process of tissues, increasing the risk of developing fibrotic plaques and potentially being proposed as possible causes of Peyronie.
Peyronie’s disease can have multiple causes, from microtraumas to genetic factors or metabolic diseases. Before opting for surgery or other treatments for Peyronie’s disease, it is essential to determine the reasons for its development. To do so, we conduct a detailed study of each case to identify the origin and offer the most suitable treatment.
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