The process works through a mechanism that responds to tension or pressure. Special sensors, such as cadherins and integrins, are activated, which in turn activate ionic channels and send signals through the cell skeleton. These signals trigger a series of reactions within the cell, involving molecules such as IP3, DAG, cyclic D1, and PDGF. In laboratory in vitro studies, it has been observed that tension increases the production of certain enzymes (MMP8) and reduces the production of a protein called α-actin.
Among the most commonly used devices in our clinic are the TractionPen System from AndroGenital® and the Penile Traction Therapy Device from Restorex®.